首先你得有 PyPI 的账号，没有注册的话，不用搞了。
然后你肯定要先准备 setup.py 了，如果这个都没弄就不用搞了。

算了，先贴一个简单的样板吧。

setup.py

# -*- coding: utf-8 -*-

from setuptools import setup

setup(
    name='PageageName',
    version='0.0.1',
    author='YourName',
    author_email='YourEmail',
    url='PackageSite (e.g. GitHub)',
    description='....',
    long_description=open('README.md').read(),
    long_description_content_type='text/markdown',
    packages=['PackageDir'],
    install_requires=[
        'requests>=2.18.4',
        'balabala',
    ],
    extras_require={  # 可选
        'dev': [
            'balabala...',
        ],
        'test': [
            'balabala...',
        ],
    },
    classifiers=[
        'Development Status :: 3 - Alpha',
        'Programming Language :: Python',
        'Programming Language :: Python :: 2',
        'Programming Language :: Python :: 2.7',
        'Programming Language :: Python :: 3',
        'Programming Language :: Python :: 3.6',
        'Programming Language :: Python :: 3.7',
        'Programming Language :: Python :: 3.8',
        'License :: OSI Approved :: MIT License',
    ],
)

流程

python3 -m pip install twine

rm -rf dist

python3 setup.py sdist bdist_wheel
python2 setup.py sdist bdist_wheel

twine upload dist/*

twine 会询问账号密码，如果不想每次这么麻烦，可以创建 ~/.pypirc 文件。

.pypirc 文件

[distutils]
index-servers =
    pypi

[pypi]
repository = https://upload.pypi.org/legacy/
username = your_username
password = your_password

参考资料

• PyPI, twine
• ReadTheDocs, twine documentation
• Python, The .pypirc file